The most adopted NIST frameworks and standards include the NIST Cybersecurity Framework (CSF), NIST SP 800-171, NIST SP 800-53, and the Risk Management Framework (RMF). The applicable framework depends on whether your organization handles federal information, controlled unclassified information (CUI), supports regulated industries, or operates under contractual cybersecurity obligations. Selecting the correct framework and defining its scope is the first critical implementation decision.